H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profilesArticle Published on 2023-02-012023-06-22 Journal: The Journal of Infection [Category] 조류인플루엔자, [키워드] China H3N8 Phylogeny Receptor binding virulence wild birds. [DOI] 10.1016/j.jinf.2022.10.023 PMC 바로가기
Characterization and Function of Glycans on the Spike Proteins of SARS-CoV-2 Variants of ConcernArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] glycosylation pattern neutralization Receptor binding SARS-CoV-2 variants of concern. [DOI] 10.1128/spectrum.03120-22 PMC 바로가기
SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong KongArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] age Anti-RBD IgG antibody children consequence COVID-19 diagnosed group Health healthcare Hong Kong IgG incidence individual Infection lowest measure nucleoprotein Older omicron ORF8 Public Receptor binding Receptor binding domain reflect SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection seropositive serosurveillance. subclinical infection vaccination variant [DOI] 10.1080/22221751.2022.2106899 PMC 바로가기
Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylationArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while [DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기
De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsArticle Published on 2022-10-282022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Antiviral binding coronavirus Critical de novo evade exhibited hACE2 host cell hotspot human Angiotensin-converting enzyme immune in vitro Interaction Ligand Neutralizing nucleic acids Occurrence omicron peptide Prophylaxis random reagents Receptor binding receptors recruit SARS-CoV-2 SARS-CoV-2 variant selected Tolerance Vaccine variant variants viral variant virus [DOI] 10.1126/sciadv.abq6207 PMC 바로가기
Reduced B cell antigenicity of Omicron lowers host serologic responseArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response Antibody titer antigenicity B cell Breakthrough infection common cold coronavirus computational structural biology conserved CP: Immunology CP: Microbiology cross-reactivity deep learning ELISA Epitopes evade explain feature geometric Host Infection less Lower mechanism Mice immunization experiment mutated Neutralizing omicron Omicron variant of concern RBD RBS Receptor binding Receptor binding domain receptor binding site reduced reduction reduction in reveal SARS-CoV-2 Serologic response serological response serum Spike protein spike protein. trajectory vaccine-induced antibody variant variants viral evolution [DOI] 10.1016/j.celrep.2022.111512 PMC 바로가기
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019Article Published on 2022-10-172022-11-16 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome alkaline Anosmia cause Cell coronavirus COVID-19 D614G D614G mutation Efficiency Express expressing host cell hydrophobic less Loss of Smell Mucus Mutation olfactory dysfunction Olfactory epithelium olfactory function omicron Omicron variant penetration potential mechanism Prevalence Prevalence. Receptor binding reduce reduced SARS-CoV-2 Support target cell tissue tropism TMPRSS2 transmembrane serine protease variants [DOI] 10.1093/infdis/jiac113 PMC 바로가기
The Performances of Three Commercially Available Assays for the Detection of SARS-CoV-2 Antibodies at Different Time Points Following SARS-CoV-2 InfectionArticle Published on 2022-10-052022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome antibody antibody assay Antibody test assays calculated Clinical practice coronavirus detection diagnostic sensitivity different time point ELISA epidemiological studies evaluate IgG IgG test nucleocapsid PCR positivity performance performed Point positive Predictive RBD RBD IgG Receptor binding Receptor binding domain reduced remained S1/S2 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 RBD SARS-CoV-2 spike sensitivity sera specificity spike Spike. tested time [DOI] 10.3390/v14102196 PMC 바로가기
Longitudinal Systemic and Mucosal Immune Responses to SARS-CoV-2 InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age Antibody Response binding antibody Blood breadth Control coronavirus coronavirus disease correlated correlation COVID-19 determine disease severity domain evaluated IgA IgM Immunity Immunoglobulin implication independent individuals Infection longitudinal mucosal mucosal immunity. multiplex nasal neutralization Neutralizing neutralizing response observation occurred Participants pseudovirus assay RBD RBD-specific IgG Receptor binding Reinfection respiratory respiratory sample response responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion serum Spearman Stool systemic Transmission uninfected Vaccine was performed [DOI] 10.1093/infdis/jiac065 PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Variant. Viral variants virus virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기